Renal cancer bone mets
According to these aspects, the patient was included in the intermediate risk group, with detoxifiere 30 de zile survival estimated at CT exam reassessment for thorax, abdomen, and pelvis with contrast substance scans renal cancer bone mets performed in Augustand then in Januaryboth suggesting stable disease.
It was decided to continue the treatment with sunitinib, with the same doses, with good tolerance and no side effects.
In Augustthe patient was admitted to the nephrology hospital section with elevated levels of nitrates. Following investigations, there was no evidence of acute renal insufficiency and it was recommended to continue the sunitinib treatment.
The thoracic, abdominal, pelvis CT test performed on June 18, revealed multiple numerical and dimensional secondary pulmonary lesions compared to the previous exam, a stationary aspect of adrenal lesions without other secondary lesions.
Metastatic Renal Cell Carcinoma
Conclusion: disease progression. Bone scintigraphy performed on July 3, revealed a scintigraphic image without oncological interest. Figure 1. Abdominal CT scan - November 28, Following the imaging results that highlighted the disease progression, it was decided to stop the sunitinib therapy and initiate the second-line therapy. Figure 2.
Lung CT scan - July 3, The thoracic, abdominal and pelvic CT test performed on Renal cancer bone mets 4, revealed evolutionary numerical and dimensional secondary pulmonary lesions, adjacent adrenal secondary process with evolutionary aspect, mediastinal and upper abdomen pathological lymph nodes. Between December and Octoberthe patient was treated with temsirolimus, weekly dose of 25 mg i. Renal cancer bone mets 3. Abdominal CT scan - December 4, Thoracic, abdominal and pelvic CT exam performed on June 21, no contrast substance revealed: secondary lung lesions and left adrenal metastasis in mild dimensional progression compared to previous examination, without secondary liver and bone lesions.
Conclusion: stable disease. Figure 4.
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- Apasă pentru a vedea definiția originală «metastatic» în dicționarul Engleză dictionary.
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Abdominal CT scan - October 27, Bone scintigraphy on The patient continued the treatment with temsirolimus weekly with 25 mg i. Figure 5. Abdominal CT scan - January 02, In terms of side effects after temsirolimus treatment, the patient experienced repeated haematological toxicity, grade thrombocytopenia between March and Julywhich led to discontinuing the treatment and repeated platelet transfusion.
The renal cancer bone mets is resumed in Augustafterwards — no side renal cancer bone mets.
Înțelesul "metastatic" în dicționarul Engleză
The thoracic-abdominal-pelvic native CT scan performed on October 10th, revealed secondary lung lesions in dimensional regression from previous examination; without new lesions, the secondary lesion of the left adrenal gland in mild dimensional regression, but spontaneous hypodense liver lesion developed in left hepatic lobe, suspected for secondary substrate, mediastinal and infradiafragmatic adenopathies in mild dimensional regression.
Conclusion: disease progression due to new hepatic secondary lesion. Figure 6. In Novemberhepatic chemoembolization with tandem microspheres loaded with doxorubicin mg renal cancer bone mets performed.
METASTATIC - Definiția și sinonimele metastatic în dicționarul Engleză
Between December and Januarythe patient continued temsirolimus 25 mg i. In January 1st,a new thoraco-abdominal-pelvic CT scan was performed, which showed local right renal lobe relapse, secondary hepatic evolution dimensional and numerical tumors, stable secondary pulmonary metastases, renal cancer bone mets adrenal glands lesions with dimensional evolution, and an osteolytic renal cancer bone mets vertebral body L2 - possibly secondary.
It was decided to discontinue the treatment with temsirolimus, renal cancer bone mets to evaluate the following therapeutic options. In Marchthe patient suffered a left femoral fracture by falling from his own height, for which a surgical intervention was performed on March 6th,in another clinical hospital osteosynthesis with trans-trohantero-cervico-cephalic screws.
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During hospitalization, the patient had increased serum calcium levels Bone scintigraphy performed on March 20th, revealed secondary vertebral bone metastases T10, T12, L2and bilateral femur metastases.
On April 12 - April 14,the patient was once again hospitalized on the nephrology section with low back pain and inferior limb pain, renal cancer bone mets diagnosis of admission being: chronic dorsolombalgia, high blood pressure grade 3, very high risk group, insulin-requiring type 2 diabetes, right nephrectomy for Gravitz tumor operated with pulmonary, renal cancer bone mets adrenal and liver metastases, asymptomatic hyperuricaemia, mixed caused hypercalcemia.
In April 19th,the patient returned to the Institute of Oncology with balanced hemodynamic and respiratory status, and functional impotence in the left limb.
Biological status: anemia hemoglobin 8. Regarding continued treatment options, at the time the patient did not fit renal cancer bone mets any of the inclusion renal cancer bone mets according to the current therapeutic protocols, axitinib being approved in second-line therapy, and everolimus treatment was not renal cancer bone mets because of the low hemoglobin level and clearence to creatinine.
Also, the actual protocols do not accept the rechallenge therapy for sunitinib, and immunotherapy was not available at that time for renal carcinoma. On April 20th,supportive treatment was initiated: erythropoietin weekly, intravenous administration, to normalize hemoglobin level, and intensive hydration renal cancer bone mets decrease creatinine levels. Therefore, the patient started oral administration of everolimus at 10 mg dose per day.
In June the patient performed external RT with palliative indication at the level of bone secondary determinations and continued to administer everolimus, with good tolerance. Discussions What is to be emphasized is that under four targeted therapy lines, the patient showed an overall survival of 45 months after metastatic disease revealed and 49 months after the diagnosis of renal clear cell carcinoma, compared to the average survival period statistically estimated to be In order to have a correct therapeutic attitude, the following steps are essential for patients with clear kidney tumors: histological confirmation of the diagnosis, subsequently verified by immunohistochemical tests, correct staging, patient framing renal cancer bone mets in one of the risk groups, correct evaluation of prognostic factors, control of co-morbidities and the possibility of performing nephrectomy 3.