Endocrine Abstracts

Papillary thyroid cancer vascular invasion. Sub Tiroida Sem 2

Reprezinta cresterea de volum a glandei tiroide, prin prezenta unor noduli, unici sau multipli, pastrand un nivel normal de hormoni tiroidieni. Este un termen enspecific care defineste cresterea tiroidei in talie si in greutate de cause diverse, la persoanele eutiroidiene, hipotiroidiene sau hipertiroidiene.

Etiopatogenie: 1. Defectul genetic de sinteza de papillary thyroid cancer vascular invasion tiroidieni, apare in gusa congenitala- hormonii tiroidieni fiind insuficienti, hipofiza stimuleaza sinteza de hormone tropi, cee ace implica proliferarea epiteliului follicular tiroidian cu hiperplazia secundara a acestuia.

Goatrogenii varza si conopida si unele medicamenete, interfera cu productia de hormone tiroidieni si aparitia gusei.

papillary thyroid cancer vascular invasion

Gusa nodulara non toxica: este o crestere a tiroidei pe seama unei hiperplazii continute sau repretitive in raspunsul deficient de hormone secretati de glanda tiroida.

Clinic: Se observa masa cervicala ce comprima structurile din jur si determina simptome ca dispnee si disfagie; uneori poate fi prezent un nodul tiroidian hiperfunctional toxicsi se numeste sd.

DNMT1 expression in papillary thyroid carcinoma

Plummer, iar clinic pacientul prezinta hipertiroidism. Tiroida poate fi crescuta in talie, sa ajunga pana la de grame. Se poate extinde substernal sis a determine detresa respiratorie. Macroscopic: - gusa difuza: glanda marita uniform de volum mai mult de 40gsimetric, cu aspect cenusiu, translucid, sticlos din cauza prezentei coloidului; papillary thyroid cancer vascular invasion gusa nodulara — marire de volum asimetrica, cu aspect multinodular pe sectiune; nodulii au aspect brun-galbui sau brun-roscat, gelatinos, in functie de cantitatea de coloid; nodulii sunt incapsulati; frecvent se observa zone hemoragice, chistice de scleroza si de calcificare.

Microscopic: Gusa difuza prezinta hiperplazie si hipertrofie difuza a epiteliului folicular, ocazional formand papillary thyroid cancer vascular invasion papilare; pe masura ce afectiunea se cronicizeaza, cu episoade de stimulare si involutie administrare de iodaspectul coloid si nodular devind evident, cu foliculi dilatati chistic si epiteliu aplatizat sau cuboidal, nodulii au dimensiuni variabile si sunt separati prin septuri fibroase; frecvent se identifica zone de calcificare, scleroza, hemoragie si depozite de hemosiderina.

Two morphologic forms of goitre are distinguished: A. Diffuse goitre simple nontoxic goitre or colloid goitre. Nodular goitre multinodular goitre or adenomatous goitre.

papillary thyroid cancer vascular invasion

Pathogenesis of Goitre The pathogenetic mechanisms of both forms of goitre can be considered together since nodular goitre is generally regarded as the end-stage of long-standing simple goitre Fig. The fundamental defect is deficient production of thyroid hormones due to various etiologic factors described below, but most common is dietary lack of iodine.

Deficient thyroid hormone production causes excessive TSH stimulation which leads to hyperplasia of follicular epithelium as well as formation of new thyroid follicles. Cyclical hyperplastic stage followed by involution stage completes the picture of simple goitre. Repeated and prolonged changes of hyperplasia result in papillary thyroid cancer vascular invasion growth of thyroid tissue while involuted areas undergo fibrosis, thus completing the picture of nodular goitre.

Nicolau Institute of Virology, Bucharest, Romania. Introduction: In human papillary thyroid cancer vascular invasion cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Design: 49 patients aged 10–82 years hospitalized for thyroidectomy were included between January and July The inclusion criterion was patients with thyroid nodules with indication for surgery and the exclusion criteria were: hyperthyroidism, medullary thyroid carcinoma, thyroid metastasis, other thyroid tumors, and anaplastic thyroid carcinoma.

Diffuse Goitre Simple Non-toxic Goitre, Colloid Goitre Diffuse, nontoxic simple or colloid goitre is the name given to diffuse enlargement of the thyroid gland, unaccompanied by hyperthyroidism. Most cases are in a state of euthyroid though they may have passed through preceding stage of hypothyroidism due to inadequate supply of iodine. TSH levels are invariably elevated. In general, goitre is more common in females. Simple goitre often appears at puberty or in adolescence, following which it may either regress or may progress to nodular goitre.

Epidemiologically, goitre occurs in 2 forms: endemic, and non-endemic or sporadic. Endemic goitre. Such endemic papillary thyroid cancer vascular invasion are several high mountainous regions far from the sea where iodine content of drinking water and food is low such as in the regions of the Himalayas, the Alps and the Ande.

Of late, however, the prevalence in these areas has declined due to prophylactic use of iodised salt. Though most endemic goitres are caused by dietary lack of iodine, some cases occur due to goitrogens and genetic factors. Goitrogens are substances which interfere with the synthesis of thyroid hormones. These substances are drugs used in the treatment of hyperthyroidism and certain items of food such as cabbage, cauliflower, turnips and cassava roots. Sporadic non- endemic goitre.

Non-endemic or sporadic simple goitre is less common than the endemic variety. In most cases, the etiology of sporadic goitre is unknown. A number of causal influences have been attributed. These include the following: Suboptimal iodine intake cancerul endometrial simptome conditions of increased demand as in puberty and pregnancy.

Genetic factors. Dietary goitrogenes. Hereditary defect in thyroid hormone synthesis and transport dyshormonogenesis. Inborn errors of iodine metabolism.

Grossly, the enlargement of the thyroid gland in simple goitre is moderate weighing up to gmsymmetric and diffuse. Cut surface is gelatinous and translucent brown Fig.

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Histologically, two stages are distinguished: 1. Hyperplastic stage is the early stage and is characterised by tall columnar follicular epithelium showing papillary infoldings and formation of small new follicles. Involution stage generally follows hyperplastic stage after variable period of time. This stage is characterised by large follicles distended by colloid and lined by flattened follicular epithelium Fig.

Nodular Goitre Multinodular Goitre, Adenomatous Goitre As already stated, nodular goitre is regarded as the end-stage of long-standing simple goitre. It is characterised by most extreme degree of tumour-like enlargement of the thyroid gland and characteristic nodularity.

The enlargement of the gland may be sufficient to not only cause cosmetic disfigurement, but in many cases may cause dsyphagia and choking due to compression of oesophagus and trachea.

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Since nodular goitre is derived from simple goitre, it has the same female preponderance but affects older individuals because it is a late complication of simple goitre.

Etiologic factors implicated in endemic and nonendemic or sporadic variety of simple goitre are papillary thyroid cancer vascular invasion in the etiology of nodular goitre too.

However, how nodular pattern is produced is not clearly understood.

Sub Tiroida Sem 2

Possibly, epithelial hyperplasia, generation of new follicles, and irregular accumulation of colloid in the follicles—all contribute to produce increased tension and stress in the thyroid gland causing rupture of follicles and vessels.

This is followed by haemorrhages, scarring and sometimes calcification, resulting in development of nodular pattern. Grossly, the thyroid in nodular goitre shows asymmetric and extreme enlargement, weighing gm or even more. The five cardinal macroscopic features are as under Fig.

Sub Tiroida Sem 2

Nodularity with poor encapsulation 2. Fibrous scarring 4. Focal calcification 5. Cystic degeneration.

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Cut surface generally shows multinodularity but occasionally there may be only one or two nodules which are poorly- circumscribed unlike complete encapsulation of thyroid adenoma, described below. Histologically, the same heterogenicity papillary thyroid cancer vascular invasion seen on gross appearance is seen.

Corresponding microscopic features are papilloma ceppo 66 follows Fig. Partial or incomplete encapsulation of nodules. The follicles varying from small to large and lined by flat to high epithelium. A few may show macropapillary formation. Areas of haemorrhages, haemosiderin-laden macrophages and cholesterol crystals. Fibrous scarring with foci of calcification.

Micro-macrocystic change. Este cea mai frecventa cauza de hipertiroidism la persoanele sub 40 de ani, are incidenta maxima intre ani si un raport de in favoarea femeilor.

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Etiologie: factori genetici, mecanisme imune. Are porbabil, un mechanism immunologic si obisnuit este asosciata cu alte leziuni autoimmune. Clinic: semnele hipertiroidismului: bolnavii afectati sunt femei tinere cu manifestari enrvoase, tahicardie, transpiratii, pierdere in greutate si exoftalmie. Nivelul tireotropinei este scazut sau nesesizabil.

Papillary thyroid cancer vascular invasion Tiroida este marita difuz de ori, bilateral; gusa are o consistenta ferma, aspect neted si o culoare rosu-brun pe suprafata de sectiune. Microscopic: Foliculii tiroidieni sunt hiperplazici, cu epiteliu cubic-cilindric si proeminente papilare fara ax conjunctiv in lumen; la polul apical al celulelor exista vacuole de resorbtie, sugestive pentru hiperfunctie metabolica a celulelor foliculare; Coloidul este redus, cu aspect crestat festonat marginal; interstitial se gaseste infiltrat inflamator si chiar agregate limfocitare nodulare fomate din limfocite T; administrarea preoperatorie de iod determina involutia si dilatarea foliculilor, cu aplatizarea epiteliului si fibroza interstiala; - tesutul periorbital prezinta initial edem apoi fibroza in infiltrare limfocitara.

Celulele foliculare sunt inalte, columnare, cu nuclei amrita. Stroma este intens vascularizata si infiltrate cu limfo monocyte. The disease is more frequent between the age of 30 and 40 years and has five-fold increased prevalence among papillary thyroid cancer vascular invasion. These are as follows: 1. Genetic papillary thyroid cancer vascular invasion association.

A familial occurrence has been observed. Autoimmune disease association. Other factors.

Depending upon its action as inhibitory or stimulatory to follicular epithelium, it may result in alternate episodes of hypo- and hyperthyroidism. The evidence in support is the intense lymphocytic infiltrate around the ocular muscles and detection of circulating autoantibodies against muscle antigen that cross-react with thyroid microsomes.

Grossly, the thyroid is moderately, diffusely and symmetrically enlarged and may weigh up to gm. On cut section, the thyroid parenchyma is typically homogeneous, red- brown and meaty and lacks the normal translucency. Histologically, the following features are found Fig. There is considerable epithelial hyperplasia and hypertrophy as seen by increased height of the follicular lining cells and formation of papillary infoldings of piled up epithelium into the lumina of follicles which are small.

DNMT1 expression in papillary thyroid carcinoma | ECE

The colloid is markedly diminished and is lightly staining, watery and finely vacuolated. The stroma shows increased vascularity and accumulation of lymphoid cells.

However, the pathologic changes in gross specimen as well as on histologic examination are considerably altered if preoperative medication has been administered. Iodine administration results in accumulation of colloid in the follicles and decrease in vascularity and height of follicular cells, while antithyroid drugs such as thiouracil cause marked hyperplasia. Patients are usually young women who present with symmetric, moderate enlargement of the thyroid gland with features of thyrotoxicosis pageophthalmopathy and dermatopathy.

Ocular abnormalities are lid lag, upper lid retraction, stare, weakness of eye muscles and proptosis. In extreme cases, the lids can no longer close and may produce papillary thyroid cancer vascular invasion injuries and ulcerations. Troidita Hashimoto Papillary thyroid cancer vascular invasion inflamatorie autoimuna a tiroidei caracterizata prin prezenta de anticorpi ce distrug treptat foliculii tiroidieni.

Frecvent se asociaza si alte leziuni de natura autoimuna, inclusive leziuni endocrine. Macroscopic: Glanda tiroida marita de volum de papillary thyroid cancer vascular invasion, difuz, simetric, bilateral; are o consistenta ferma greutate intre g, capsula intacta; pe suprafata de sectiune are aspect carnos, de culoare galben- cenusiu, palid, lobulatia este accentuate si lobii individuali proemina.

Microscopic: Interstitul tiroidian intre foliculi prezinta un bogat infiltrat inflamator limfo-mononuclear limfocite si plasmocitecu formare de foliculi limfoizi cu centru germinativ; - Foliculii tiroidieni sunt atrofici si redusi numeric si mici. Infiltratul de limfoplasmocite cu formarea de centri clari asemeni unui limfom nodular este proeminent iar fibroza are grade variate de extindere. Diffuse goitrous enlargement of the thyroid.

Lymphocytic infiltration of the thyroid gland. Occurrence of thyroid autoantibodies. Though rare in children, about half the cases of adolescent goitre are owing to autoimmune thyroiditis.

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Hashimoto, a Japanese surgeon, described it in as the first auto immune disease of any organ. It appears that TSH-receptor antibody may act both to depress or stimulate the thyroid cells to produce hypo- or hyperthyroidism respectively. Thus, these patients may have alternate episodes of hypo- or hyperthyroidism. Genetic basis: The disease has higher incidence in firstdegree relatives of affected patients.

Endocrine Abstracts

Grossly, the classic form is characterised by diffuse, symmetric, firm and rubbery enlargement of papillary thyroid cancer vascular invasion thyroid which may weigh gm. Sectioned surface of the thyroid is fleshly with accentuation of normal lobulations but with retained normal shape of the gland.

The fibrosing variant has a firm, enlarged thyroid with compression of the surrounding tissues. Histologically, the classic form shows the following features Fig.

Не мешкая, Сирэйнис поднялась и стала медленно прохаживаться по крыше. -- Я знаю, о чем вы собираетесь спрашивать,-- начала. -- На papillary thyroid cancer vascular invasion из этих вопросов я могу дать ответ, но делать это с помощью слов было бы слишком утомительно.

Если вы откроете мне свое сознание, я передам ему все, что вам хочется узнать. Можете мне довериться; без вашего разрешения я не прочту ни мысли.

There is extensive infiltration papillary thyroid cancer vascular invasion the gland by lymphocytes, plasma cells, immunoblasts and macrophages, with formation of lymphoid follicles having germinal centres. There is decreased number of thyroid follicles which are generally atrophic and are often devoid of colloid. The follicular epithelial cells are transformed into their degenerated state termed Hurthle cells also called Askanazy cells, or oxyphil cells, or oncocytes.

These cells have abundant oxyphilic or eosinophilic and granular cytoplasm due to large number of mitochondria and contain large bizarre nuclei. There is slight fibrous thickening of the septa separating the thyroid lobules. It can occur at all ages including children and young adults but the incidence is higher with advancing age.

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The tumour is found about three times more frequently in females than in males. Papillary carcinoma is typically a slow-growing malignant tumour, most often presenting as an asymptomatic solitary nodule.

К северу на многие километры тянулся лес, там и сям прорезанный полянами, лугами и извилистыми нитями множества речушек. Где-то в этой бескрайней панораме пряталось село Эрли, но пытаться отыскать его было делом совершенно безнадежным.

Элвину лишь ненадолго показалось, что он заметил озеро, мимо которого вела дорога в Лис. Еще дальше к северу деревья и поляны терялись в крапчатом зеленом ковре, морщинившемся кое-где грядами холмов. А еще дальше, на самом пределе видимости, подобно облачному валу, лежали горы, отсекавшие Лис от пустыни.

Involvement of the regional lymph nodes is common but distant metastases to organs are rare. Some cases first come to attention by spread to regional lymph nodes and cause cervical lymphadenopathy.

Grossly, papillary carcinoma may range from microscopic foci to nodules upto 10 cm in diameter and is generally poorly papillary thyroid cancer vascular invasion. Cut surface of the tumour is greyish-white, hard and scar-like Fig. Sometimes the tumour is transformed into a cyst, into which numerous papillae project and is termed papillary cystadenocarcinoma.

Histologically, the following features are present Fig. Papillary pattern.