Terapia hormonala - Totul despre acest tratament oncologic

Cancer hormonal therapy

Dovezi științifice

It is applied in patients expressing cancer hormonal therapy hormone receptors ER - estrogen receptor and PGR - progesteron receptor. It is possible that HER2 human epitelial growth factor receptor 2 to have an influence on the response or resistance to hormonal treatment.

This article presents the main classes of drugs used in hormonal treatment and their indication, improvements cancer hormonal therapy and future perspectives of research.

El este aplicat la pacientele la care se identifică în ţesutul tumoral prezenţa receptorilor cancer hormonal therapy ER - receptor estrogen şi PGR - receptor progesteron. Este posibil ca şi statusul HER2 receptorul 2 al factorului de creştere epidermal uman să aibă influenţă asupra răspunsului şi rezistenţei la tratamentul hormonal.

Articolul are drept scop prezentarea principalelor clase de medicamente folosite în tratamentul hormonal şi cancer hormonal therapy prinicipalelor indicaţii, progrese înregistrate şi perspective de viitor.

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Cuvinte cheie tratament hormonal cancer de sân modulatori selectivi ai receptorului de estrogen inhibitori de virus de papiloma humano repite Introduction Hormones are molecules that act like chemical messengers in the human body. Their main circulating path is cancer hormonal therapy the blood stream.

Estrogen and progesteron are made in the ovaries in premenopausal women, and in other tissues including fat in postmenopausal women.

Apart from their classic role female sex characteristics, pregnancy etc. To determine the hormonal status, tissue from the tumour is needed.

Datorită caracteristicilor sale, acest produs satisface nevoia extrem de ridicată de micronutrienti în acest domeniu. Terapia hormonală este cel mai des utilizată pentru a trata cancerele de sân și de prostată, unde rolul său este bine stabilit.

It can be obtained either by biopsy, or by surgery. Main hormone therapy classes Blocking ovarian function - ovaries are the main production site of estrogen in premenopausal women. Blocking of their function can be achieved by either removing ovaries surgically, or by radiation both being definitive methods or, most frequently used today, inhibiting their function temporarily by using  gonadotropin releasing hormone GnRH agonists or luteinizing hormone releasing hormone LH-RH agonists.

Examples: goserelin and leuprolide. The main side effects of these therapies are bone loss, mood swings, cancer hormonal therapy, cancer hormonal therapy loss of libido.

cancer hormonal therapy Blocking estrogen production - aromatase inhibitors AI are used to block the production of estrogens from fat and other tissues. They can be given alone in postmenopausal women or in association with ovarian suppression in premenopausal setting.

Examples: anastrozole, letrozole - both inactivate temporarily the aromatase enzyme non-steroidal AI - or exemestane, which inactivates the enzyme permanently steroidal AI. The main side effects are: risk of heart attack, angina, heart failure, and hypercholesterolemia, bone loss, joint pain, mood swings and depression.

Blocking estrogens effects - two drugs block the action of estrogen on the breast tumour cells. Selective estrogen receptor modulating agents SERMs : they bind to the receptor, blocking it, thus preventing the binding of estrogen. cancer hormonal therapy

Study Looks at Relationship between Breast Cancer and Hormone Therapy (HD) FOR MEDIA

Examples: tamoxifen and toremifen. They act like antagonists in some tissues tumour cells and agonists in other cancer hormonal therapy, boneinfluencing their safety profile.

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Common adverse reactions: risk of blood clots, especially in the lungs and legs, stroke, cataract, endometrial cancer, bone loss in premenopausal women. Other antiestrogen drugs, like fulvestrant: they act similarly to tamoxifen, but without the agonist effect. Furthermore, after binding to the estrogen receptor, they programme it for destruction.

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This explains the better safety profile and side effects: gastrointestinal symptoms, elevated liver functional tests, loss of strength and pain Taking into account the medical history of patients and other treatments they are undergoing, we must be careful for interactions.

For tamoxifen, caution must be cancer hormonal therapy for patients in treatment with antidepressants from the class of selective serotonin reuptake inhibitors SSRI like paroxetine, which inhibits enzyme CYP2D6.

cancer hormonal therapy

They slow down tamoxifen metabolization and reduce its effects. Safer alternatives are available, like sertraline, venlafaxine or even considering changing tamoxifen with AI.

Actualizări în tratamentul hormonal al cancerului de sân

Treatment protocols Prevention. The same indication for AI is still under investigation 8. There have been several studies investigating this option, mainly using AI. The cancer hormonal therapy is to ob­tain tumour shrinkage in order to allow breast conserving surgery. Although there are promising results, cancer hormonal therapy such therapies are not approved for this indication 9.