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Perianal squamous papilloma histology, Revista Societatii de Medicina Interna

Cancerul de canal anal - aspecte legate de diagnostic și tratament

Sign up Log in cancerul de canal anal Anal canal cancer diagnosis and treatment aspects Cancerul de canal anal - aspecte legate de diagnostic și tratament Şerban Marinescu1, Angela Perianal squamous papilloma histology Lazăr1,2, Laurenţiu Simion1,2, Alexandru C. Grigorescu3 1.

This review focuses on the main diagnostic and treatment aspects concerning anal canal cancer. Anal abdominal cancer cells incidence has been increasing in the last years, probably due to the rise in the spread of sexually transmitted diseases, such as HPV and Perianal squamous papilloma histology infections.

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Although many risk factors have been associated to anal cancer HPV, HIV perianal squamous papilloma histology, immunocompromised status, tobacco smokinganal cancer biology is only partly understood. Anal canal cancer should be distinguished from anal margin cancer, which is of better prognosis.

Dan L. ClinicilorCluj ddumitrascu umfcluj. Aceast articol încearcă să sumarizeze literatura actuală despre epidemiologia, fiziopatologia, diagnosticul şi tratamentul acestor leziuni. Cu toate că descoperirile din domeniile cercetării moleculare şi farmacologice au reuşit să trateze numeroase maladii, eficienţa tratamentelor existente până în prezent pentru condiloamele acuminate este suboptimală.

Anal cancer diagnosis is usually delayed, due to its resemblance to benign perianal pathology that justifies the need for a better screening. Anal canal carcinoma therapeutic management has witnessed a major shift in time from a radical surgical abdominoperineal resection to multimodal approach.

From the irst reports of the disease, in mid- inversa, inliximab, 19th century, our understanding of HS has evolved so that today it treatment anti TNF is considered a disease of follicular obstruction with the possibility alpha of a defective basement membrane at the sebofollicular junction of the folliculopilosebaceous unit rather than an infectious process of the apocrine glands. The recent discovery of bacterial bioilm involvement in HS could very well explain its resistance to antibiotic therapy. Treatment options have evolved to include multi-antibiotic therapy, laser therapy, biological treatments TNF-α and IL-1 inhibitorssurgical treatment options and electrosurgical procedures. Despite all these progresses, may patients continue to struggle with the pain, odor, embarrassment and frustration that Cite this article: Mihai Lupu, Cristiana Voicu, accompany this isolating disease. HS is misunderstood by patients Laura Papagheorghe, and doctors alike, resulting in the delay of clinical presentation, Irina Tudose, Victor Gabriel diagnosis and treatment.

Nowadays, the standard treatment of anal carcinoma is represented by radiochemotherapy that is an effective therapy although can associate an important toxicity. Surgical treatment is reserved only to very small anal lesions and especially to residual disease or tumor perianal squamous papilloma histology after primary therapy, representing a salvage therapy abdominoperineal rectal amputation for these cases.

Revista Societatii de Medicina Interna

Inguinal lymphadenectomy is only indicated for voluminous lymphadenopathy blocks and inguinal lymph node metastases appeared after radiochemotherapy. Acest review vizează surprinderea principalelor aspecte de diagnostic și tratament privind cancerul de canal anal. Incidența cancerului anal a suferit o creștere în ultimii ani, probabil din cauza accentuării răspândirii infecțiilor cu transmitere sexuală, precum infecția cu HPV și HIV.

Deși mulți factori perianal squamous papilloma histology risc au fost asociați cu cancerul anal infecția cu HPV, HIV, statusul imunocompromis, fumatulbiologia cancerului anal rămâne doar parțial înțeleasă.

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Cancerul de canal anal ar trebui diferențiat de cancerul de margine anală, care asociază un prognostic mai bun. Diagnosticul cancerului de canal anal este în general întârziat, din cauza asemănării sale cu patologia perianală benignă, ceea ce justifică necesitatea unui screening îmbunătățit.

Managementul terapeutic al carcinomului anal a înregistrat o modificare majoră în timp, de la o abordare chirurgicală radicală amputația rectală abdominoperineală la o terapie multimodală.

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Astăzi, tratamentul standard al cancerului anal este reprezentat de radio-chimioterapie, care reprezintă o terapie eficientă, deși poate asocia o toxicitate semnificativă. Tratamentul chirurgical e rezervat doar leziunilor anale foarte mici și în special bolii reziduale și recidivelor tumorale după terapia primară, pentru care reprezintă o terapie de salvare amputația perianal squamous papilloma histology rect abdominoperineală. Limfadenectomia inghinală e indicată perianal squamous papilloma histology pentru blocurile adenopatice inghinale voluminoase sau metastazelor ganglionare inghinale survenite după radio-chimioterapie.

Background 1. Incidence Anal canal cancer is a relatively rare tumor, representing approximately 1. It is approximately 20 to 30 times rarer than colon cancer, but its annual incidence is increasing, reaching up to cases, with a female predominance 2. There is an important geographic variation regarding its incidence, as well as histopathological type.

Cuvinte-cheie: cancer canal anal, factori de risc, diagnostic, tratament Background 1. Incidence Anal canal cancer is a relatively rare tumor, representing approximately 1. It is approximately 20 to 30 times rarer than colon cancer, but its perianal squamous papilloma histology incidence is increasing, reaching up to cases, with a female predominance 2.

There is an impor- 20 tant geographic variation regarding its incidence, as well as histopathological type. The mainstay of the treatment is represented perianal squamous papilloma histology chemo-radiotherapy, radical surgery being reserved to residual tumor or recurrences.

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