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    Methods were developed in an effort to define recommended industrial hygiene practices for petroleum workers who were assumed to cleanse skin less than once papillomas definition, and papillomas definition could thus potentially be dermally exposed to petroleum products for extended periods during the workday and beyond Holt et al.

    Methods were based on investigatory work conducted over the previous 20 years Twort and Twort, ; Spicer, ; Papillomas definition, Positive control: 3-methylcholanthrene 3-MC Observations and examinations performed and frequency: The study focussed on the potential of the test material to papillomas definition definition skin tumours; other observations were limited.

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    Mice were examined on treatment days for general health and well-being, and observed monthly for tumour incidence. Whenever a papillomas definition was first noted by handlers, its nature was verified by the lead scientist and its position noted diagramatically.

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    Progression or regression of the growth was documented similarly. The number of surviving mice in a given dose group was documented for each observation point. Sacrifice and pathology: Moribund or dead mice were submitted for necropsy and the results recorded.

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    Tumours were preserved and examined histologically for confirmation of tumour type. Other examinations: Data recorded in support of statistical analysis Blanding et al.

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    papillomas definition That is, the numerator measures the total response for both living and dead mice, the word tumour was used papillomas definition differentiation between benign and malignant forms. The denominator is computed as the original number of mice less the number that have died without any tumours up to the time of observation.

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    papillomas definition Similarly, a percent cancer response was calculated for each time of observation. Percent tumour or percent cancer response was plotted against time logarithmically to obtain laser treatment for laryngeal papilloma dose-response line probit plot. The denominator was derived from the logarithmic plot described above.

    Papillomas definition analogous calculation was done for cancer potency.

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    This was compared for the test substance vs. Clinical signs: Dermal irritation if dermal study : not examined.

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