Neuroendocrine cancer xenograft, Jurnale medicale Radiologie - imagistica medicala, 2012, Martie
Ann Anat ;Sep. Histologically, there are four types of fat tissue cells which are currently recognized white, brown, beige, and perivascular adipocytes.
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Therefore, in this study we are reviewing the most recent data regarding the origin, structure, neuroendocrine cancer xenograft molecular mechanisms involved in the development of adipocytes. White adipocytes can store triglycerides as a consequence of lipogenesis, under the regulation of neuroendocrine cancer xenograft hormone or leptin and adiponectin, and release fatty acids resulted from lipolysis, under the regulation of the sympathetic nervous system, glucocorticoids, TNF-α, insulin, and natriuretic peptides.
Brown adipocytes possess a mitochondrial transmembrane protein thermogenin or UCP1 which allows heat generation. Recently, thermogenic, UCP positive adipocytes have been identified in the subcutaneous white adipose tissue and have been named beige adipocytes.
The nature of these cells is still controversial, as current theories are suggesting neuroendocrine cancer xenograft origin either by transdifferentiation of white adipocytes, or by differentiation from an own precursor cell. Perivascular neuroendocrine cancer xenograft surround most of neuroendocrine cancer xenograft arteries, exhibiting a supportive role and being involved in the maintenance of intravascular temperature. Thoracic perivascular adipocytes resemble brown adipocytes, while abdominal ones are more similar to white adipocytes and, consequently, are involved in obesity-induced inflammatory reactions.
The factors involved in the regulation of adipose stem cells differentiation neuroendocrine cancer xenograft represent potential pathways to inhibit or to divert adipogenesis. Further investigations are necessary to complete the knowledge about adipose tissue and the development of a new generation of therapeutic tools based on molecular targets.