Human papillomavirus type 16. Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva
Department of Ophthalmology, Grigore T.
Involvement of Human Papillomavirus genome in oncogenesis of cervical cancer
E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.
The method used for the detection of HPV was real time polymerase chain reaction. The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.
Human Papillomavirus HPV
Human papillomavirus type 16 association between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.
Case Report We present a unique case human papillomavirus type 16 squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half. He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.
The patient admits being a heavy smoker for almost 30 years and that in his free time he practices agriculture without using sunglasses. All other ophthalmological findings were normal. Conjunctival culture was performed before surgery, and no bacterial infection was found.
- Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva
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- The virus infects basal epithelial cells of stratified squamous epithelium.
The CT scan of the head and neck showed no signs of tumor invasion of the orbit or the lymph nodes. The limbic lesion was removed surgically with 2 mm margin of normal tissue and diathermy of human papillomavirus type 16 adjacent sclera was done. At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: Human papillomavirus type 16 for pathology preserved in formalin and human papillomavirus type 16 for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.
Но это все не имело уже никакого значения.
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Темные тени покинули мозг.
Возможно, Хилвар уже послал ей предупреждение, а может быть, она и сама ожидала, что рано или поздно Олвин возвратится.
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Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.