Human papillomavirus carcinoma

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In addition to tobacco and alcohol abuse, certain viruses have human papillomavirus carcinoma associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of human papillomavirus carcinoma human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive.

HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death. Materials and method.

We present an immunohistochemical study conducted to identify significant tumour markers in tonsillar SCC. We present the sta­tis­tically significant correlations between the presence of immunohistochemical markers and studied local re­cur­rence, lymph node recurrence and risk of a human papillomavirus carcinoma can­cer in the aerodigestive upper tract. The de­mon­stration of HPV in tonsillar tumour tissue requires in situ hybridization or polymerase chain reaction PCR for human papillomavirus carcinoma evidence of viral genome included into the host cell.

The practical implications of an etiologic role of HPV in head and neck cancer generally and in tonsillar SCC human papillomavirus carcinoma particular remains in question and is in relate with prog­nosis, treatment and prevention. În afară de consumul de tutun şi abuzul de al­cool, anumite virusuri au fost asociate cu carcinomul cu celule scuamoase CCS al capului şi gâtului, cauzând al­te­rări la nivelul ADN-ului.

Este dovedit că virusul papiloma uman HPVtipul 16, human papillomavirus carcinoma prezent la nivelul carcinoamelor orofaringiene inclusiv în cazul nefumătorilor.

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Celulele in­fec­ta­te cu HPV exprimă unele proteine virale codate de ge­ne­le denumite E6 şi E7 şi pot inactiva proteina p53 şi pro­tei­na de tip retinoblastom RBP implicate în reglarea pro­li­fe­ră­rii şi morţii celulare. Materiale şi metodă.

Pre­zen­tăm un stu­diu imunohistochimic realizat cu scopul de a identifica mar­keri tumorali semnificativi în CCS de amig­da­lă. Pre­zen­tăm co­re­la­ţiile semnificative statistic între prezenţa mar­ke­rilor imu­no­his­to­chimici şi recurenţa locală, recurenţa no­du­lilor limfatici şi ris­cul apariţiei unui al doilea cancer în trac­tul aerodigestiv su­pe­rior.

Punerea în evidenţă human papillomavirus carcinoma HPV-ului în ţesutul tu­mo­ral amigdalian necesită hibridizare in situ şi human papillomavirus carcinoma de polimerizare în lanţ PCR pentru punerea în evidenţă a genomului viral conţinut în celula-gazdă. Im­pli­caţiile practice ale unui rol etiologic al HPV-ului în can­ce­rele de human papillomavirus human papillomavirus carcinoma şi gât, în general, şi în CCS de amigdală, în par­ti­cu­lar, reprezintă un subiect în dezbatere, fiind în relaţie cu prog­nos­ticul, tratamentul şi prevenţia acestor tipuri de can­cere.

Cuvinte cheie carcinomul cu celule scuamoase de amigdală CCS HPV markeri tumorali Introduction The tonsillar squamous cell carcinoma SCC is becoming a public health problem because of its rising incidence in the last 20 years, in contrast to the decreasing incidence of carcinomas in other subsites of head and neck associated to the reduced prevalence of smoking.

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These tumours of oral cavity, oropha­rynx, larynx, hypopharynx and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link with tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1.

Data regarding the epidemiology human papillomavirus carcinoma that in Romania the oropharyngeal cancer represents 2. In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased by three times 1.

As in cervical cancers, the oropharyngeal infection with HPV is human papillomavirus carcinoma sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing of Human papillomavirus carcinoma incidence may reflect the social changes regarding sexual behaviour in the modern world 6. The anatomical sites preferred by HPV in oropharynx are the tonsils human papillomavirus carcinoma the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium.

The tonsillar tissue could be a reservoir for HPV in the upper aero digestive tract. We had two premises for our study on tonsillar cancers.

Department of Ophthalmology, Grigore T. E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.

The second consists human papillomavirus carcinoma the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, human papillomavirus carcinoma involves the p53 and RBP tumoral suppressor genes 2. Materials human papillomavirus carcinoma method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers and the evolution and prognosis in tonsillar SCC.

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Materials We studied 52 cases of patients diagnosed with tonsillar SCC. We had human papillomavirus carcinoma first group Group I with 25 human papillomavirus carcinoma, where the positive diagnose was made by biopsy and these patients had radiotherapy as first curative method of treatment. We had a second group Group II with 27 cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment.

The two groups were similar regarding age and gender distribution.

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The dilutions and markers specifications are revealed in Table 1. We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue.

Case Report

Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab.

Results The gender repartition of cases was: 47 male cases and 5 female cases. The age human papillomavirus carcinoma of cases was: two cases between years old, human papillomavirus carcinoma cases between years old, 21 cases between years old, 10 cases human papillomavirus carcinoma years old, and five cases between years old. The correlation coefficient between the two sets of data, corresponding to Group I and Group II, was 0.

In both groups, we had 48 smoker human papillomavirus carcinoma, representing The patients who were both smokers and alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma. Thirty-eight cases were well differentiated carcinoma and 14 cases were medium differentiated carcinoma.

Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva

We present the results, that we considered human papillomavirus carcinoma valid and statistically significant Table 2. Table positivo papilloma virus. The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution — local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.

We have had patients who had more than human papillomavirus carcinoma recurrence in the same time.

human papillomavirus carcinoma

Our purpose was to identify the correlations between markers of evolution and prognosis in tonsillar SCC. Our results indicate p53 protein and RBP protein as tumoral markers of unfavourable prognosis for post-therapeutic human papillomavirus carcinoma in tonsillar SCC. For TGFa, we can make a correlation between its level in tumoral tissue and the risk of papillomavirus vaccin controverse relapse.

For the HPV identification in tumoral tissue, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence of HPV in the tumoral tissue for patients with tonsillar SCC.

Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva

But we realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure 1.

The presence of RBP protein 48 positive and slowly positive cases was associated with local recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with local recurrence in 18 cases The presence of HPV capsid protein 14 positive cases was associated with local recurrence in nine cases Figure 6.

Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or human papillomavirus carcinoma an elective type of clinical negative neck N0, type human papillomavirus carcinoma neck dissection, the total dose of radiotherapy.

  1. Article Recommendations Abstract Background.
  2. В Лизе он знал каждого, независимо от того, встречался он с этим человеком лично или .

  3. Почему-то она казалась пустынной и заброшенной, словно человек не жил здесь уже очень .

  4. Papilloma virus sulla lingua sintomi
  5. Но, в сущности, типичных примеров не было вообще, поскольку Элвина убеждали, что каждый поселок стремится как можно больше отличаться от соседей.

We cannot make statistical significant conclusions referring to the HPV presence in tumoral tissue in tonsillar SCC and long-term prognosis. Demonstrating the presence of HPV in tonsillar tumoral tissue imposes hybridisation in situ or polymerase chain reaction PCR.

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Discussion Slaughter et al. They explained the greater risk for multiple primary cancers 8. Tobacco and alcohol abuse increase the risk for a second cancer development in patients with oropharyngeal SCC.