Cancer pulmonar

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Selected References These references are in PubMed. This may not be cancer genetic environmental complete list of references from this article.


Oxygen activation by cytochrome P Annu Rev Biochem. The molecular biology of cytochrome Ps.

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Pharmacol Rev. The P superfamily: update on new cancer genetic environmental, gene mapping, and recommended nomenclature.

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DNA Cell Biol. Evolution of cytochrome P proteins.

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Mol Biol Evol. Evolution of the P gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.

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  • Human cytochromes P evolution and cDNA-directed expression.
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Trends Genet. Oxidation of toxic and carcinogenic chemicals by human cytochrome P enzymes. Chem Res Toxicol. Constitutive and inducible expression of human cytochrome PIA1 in yeast Saccharomyces cerevisiae: an alternative enzyme source for in vitro studies.

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Biochem Biophys Res Commun. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

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J Pharmacol Exp Ther. Expression of a human liver cytochrome P protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.

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Mol Pharmacol. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

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Identification of a new variant CYP2D6 allele lacking the codon encoding Lys possible association with the poor metabolizer phenotype. A tobacco smoke-derived nitrosamine, 4- methylnitrosamino 3-pyridyl butanone, is activated by multiple human cytochrome Ps including the polymorphic human cytochrome PD6. Mutagenic activation of 2-aminomethylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P Cancer Res.

J Biol Chem.

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Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process. Mutat Res. Induction of hepatocellular carcinoma in nonhuman primates by chemical cancer genetic environmental. Cancer Detect Prev. Five of 12 forms of vaccinia cancer genetic environmental human hepatic cytochrome P metabolically activate aflatoxin B1.

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Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism. A metabolically competent human cell line expressing cancer genetic environmental cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing.

Molecular genetics of the debrisoquin-sparteine polymorphism.

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Clin Pharmacol Ther. Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence. Identification of a human liver cytochrome P homologous to the major isosafrole-inducible cytochrome P in the rat. Purification and characterization of the human liver cytochromes P involved in debrisoquine 4-hydroxylation and phenacetin Cancer genetic environmental, two prototypes for genetic polymorphism in oxidative drug metabolism.

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Identification and quantitation in human liver of cytochromes P analogous to rabbit cytochromes P forms cancer genetic environmental and 6. Metabolism of N-nitrosodialkylamines by human liver microsomes.