Cancer de prostata ketoconazol
Lancet Oncol ; 20 8 :Aug. This phase trial evaluated the safety and efficacy of the hafnium oxide HfO2 nanoparticle NBTXR3 activated by radiotherapy versus radiotherapy alone as a pre-operative treatment in patients with locally advanced soft-tissue sarcoma. Sarc is a phase randomised, multicentre, international trial.
Patients had to have a WHO performance status of and a life expectancy of at least 6 months. Randomisation was stratified by histological subtype myxoid liposarcoma vs others. This was an open-label study. The primary endpoint was the proportion of patients with a pathological complete response, assessed by a central pathology review board following European Organisation for Research and Treatment of Cancer de prostata ketoconazol guidelines in the intention-to-treat population full analysis set.
Safety analyses were done in all patients who received at least one puncture and injection of NBTXR3 or at least one dose of radiotherapy. This study is registered with ClinicalTrials.
Sintomas del cancer de prostata que debes conocer
Two patients in the NBTXR3 group and one patient in the radiotherapy group were excluded from the efficacy analysis cancer de prostata ketoconazol they were subsequently discovered cancer de prostata ketoconazol be ineligible; thus, a total of patients were analysed for the primary endpoint in the intention-to-treat full analysis cancer de prostata ketoconazol 87 in the NBTXR3 group and 89 in the radiotherapy alone group.
No treatment-related deaths occurred.
Ziel der Studie ist es, die Inzidenz von Herzinsuffizienz, kardiovaskulärer Morbidität und Mortalität bei Patienten mit Prostatakrebs im Vergleich zur Gesamtbevölkerung zu bewerten. Criteriul principal final de evaluare a fost compus din morbiditatea şi mortalitatea cardiovasculară, cancer de prostata ketoconazol prin reducerea incidenţei combinate a decesului de cauză cardiovasculară, accidentului vascular cerebral şi infarctului miocardic. Der primäre Endpunkt war die Kombination aus kardiovaskulärer Morbidität und Mortalität gemessen als Reduktion der kombinierten Inzidenz von kardiovaskulärem Tod, Schlaganfall und Myokardinfarkt.